![]() A handheld flexible fiber-optic probe is commercialized by Mauna Kea Technologies, but its spatial resolution is typically lower than GRIN probes and is confined to the surface of the fiber bundle. The Coloview endoscope from Karl Stortz is optimized for tracking the tumor progression in the colon on the macroscopic size scale ( Waldner et al. ![]() ![]() Microprobes objectives from Olympus have narrower diameters (1.3–3.5 mm), but the objective has a fixed focal plane which restricts its use in live imaging ( Dela Cruz et al. offers spatial resolution similar to a GRIN probe, but the diameter of its scanning-fiber probe is relatively large (3.5–10 mm). The confocal endomicroscope made by Pentax and Optiscan, Ltd. 2007), Mauna Kea Technologies (Hsiung et al. The advances in micro-optic and fiber-optic technologies led to the emergence of several robust design strategies for miniature optical probes and commercial instruments from, for example, Pentax ( Kiesslich et al. A side-view probe is particularly suited for imaging the mucosa of tubular organs such as gastrointestinal tracts and respiratory airways ( Kim et al. A front-view GRIN probe allows in vivo imaging of internal organs after laparotomy ( Fan et al. High quality miniature optical probes can be readily fabricated with commercially available GRIN lenses into dimensions (lengths and diameters) that are well-suited for minimally invasive high-resolution imaging in small animals ( Kim et al. To overcome this constraint, endomicroscopy based on miniature optical probes has been developed, providing minimally invasive access to tissues in intact organs ( Flusberg et al. However, due to the large size of objective lenses required in these instruments, their applications have been limited mostly to superficial tissues, such as the skin, or to surgically exposed internal organs. Intravital fluorescence microscopes have been used to study a variety of cellular-level processes in vivo, such as cell trafficking, intercellular interaction, and vascular changes. Continued abuse of our services will cause your IP address to be blocked indefinitely.GRIN optical probe for intravital imaging Please fill out the CAPTCHA below and then click the button to indicate that you agree to these terms. If you wish to be unblocked, you must agree that you will take immediate steps to rectify this issue. If you do not understand what is causing this behavior, please contact us here. If you promise to stop (by clicking the Agree button below), we'll unblock your connection for now, but we will immediately re-block it if we detect additional bad behavior.
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